Acute cardiac care & resuscitation
Diabetes in resuscitated comatose out-of-hospital cardiac arrest patients: a substudy of the randomized BOX trial
Authors' conclusion
Pre-existing diabetes was associated with an increased crude 365-day mortality. No differences in outcome were observed among diabetic OHCA patients depending on the assessed blood pressure targets, oxygen levels, and durations of fever control.
Study context
- Population
- Resuscitated comatose out-of-hospital cardiac arrest (OHCA) patients randomised to BP, oxygenation and fever-control duration targets
- Comparison
- Diabetes vs no diabetes
- Diabetesn = 110
- Primary endpoint
- Survival
- Follow-up
- 365 days
Methodological detailsmulticentre, double-blind (BP targets), open-label (oxygenation, fever control)
- Multicentre
- Double-blind (BP targets)
- Open-label (oxygenation, fever control)
Primary result
As reported in the abstract
365-day all-cause mortality
P = 0.02
- Adjusted OR for diabetic patients (adjusted for age, sex, witnessed arrest, place of arrest)
- 1.47 (0.93-2.30) (P = 0.10)
Further findings
Age
Interaction of interventions with diabetes status
- No significant interactions among interventions and outcomes related to diabetes status
- P ranging from 0.10 to 0.80
Original publication
Diabetes in resuscitated comatose out-of-hospital cardiac arrest patients: a substudy of the randomized BOX trial. Eur Heart J Acute Cardiovasc Care. Published 13 May 2025. doi:10.
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