Acute cardiac care & resuscitation

Pre-hospital ECPR for refractory cardiac arrest – The PRECARE pilot feasibility study

ResuscitationPublished single-arm open-label feasibility trial

Authors' conclusion

Pre-hospital ECPR delivery by trained pre-hospital medical teams is possible and reduces OHCA low flow times. Larger studies are required to assess efficacy and cost effectiveness.

Study context

Population
Patients under the age of 70 years with refractory out of hospital cardiac arrest (OHCA), a witnessed collapse, an initial shockable rhythm and within a 45-minute radius of the mobile teampatients who received pre-hospital ECPR, of 123 confirmed cardiac arrests attended over 103 recruitment days
Participants
12 participants
Outcome
Feasibility of pre-hospital ECPR
Methodological detailspilot
  • Pilot

Main finding

As reported in the abstract

Confirmed cardiac arrests attended by the pre-hospital ECPR team

123

Patients who received pre-hospital ECPR

12

10%

Cases per shifts

one case per 8 shifts

Further findings

Time intervals

min

Mean time from dispatch to team arrival
18.5 (range 9-29)
Mean time from decision to ECMO flow
17 (range 10-34)
Mean total low flow time (arrest to ECMO flow)
39 (range 24-56)

Liberation from VA ECMO support and neurologically intact survival · hospital discharge

Successfully liberated from VA ECMO support
Four (33%)
Survived to hospital discharge neurologically intact (CPC 1-2)
3 (25%)

Original publication

Pre-hospital ECPR for refractory cardiac arrest – The PRECARE pilot feasibility study. Resuscitation. Published 12 May 2025. doi:10.1016/j.resuscitation.2025.110631

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