Lifestyle-Induced Visceral Fat Loss as a Key Target for Durable Cardiometabolic Health: MRI-Assessed 5- and 10-Year Follow-Up After 2 Clinical Trials
Authors' conclusion
This 5- and 10-year follow-up of 18-month clinical trials suggests that diet and physical activity lifestyle interventions may yield long-term improvements in cardiometabolic measures despite weight regain. A 10% reduction in visceral fat due to lifestyle interventions may reduce future type 2 diabetes risk by nearly 30%.
Study context
- Population
- Participants of the 18-month CENTRAL (2012–2014) and DIRECT-PLUS (2017–2018) lifestyle trials (dietary patterns combined with structured physical activity)of 381 eligible (96%)
- Participants
- 366 participants
- Comparison
- Intervention-induced fat depot changes and long-term cardiometabolic outcomes
Methodological detailsMRI-assessed, 5- and 10-year follow-up
- MRI-assessed
- 5- and 10-year follow-up
Primary result
As reported in the abstract
Despite complete weight regain, waist circumference and abdominal fat depots (visceral adipose tissue, deep subcutaneous adipose tissue (SAT), superficial SAT) partially preserved their intervention-induced reductions
false discovery rate ≤0.01 for all
Postintervention reductions of intrahepatic fat and intrapancreatic fat were fully and excessively regained, respectively
false discovery rate ≤0.01 for both
Original publication
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