Valvular & structural heart disease
Diffuse Interstitial Fibrosis of the Myocardium Predicts Outcome in Moderate and Asymptomatic Severe Aortic Stenosis
Authors' conclusion
Increased diffuse interstitial fibrosis of the myocardium is associated with poor outcomes in patients with moderate and asymptomatic severe AS and can help identify those who require closer surveillance for adverse outcomes.
Study context
- Population
- Patients with moderate (AVA 1.0–1.5 cm²) or asymptomatic severe aortic stenosis (AS) (AVA ≤1.0 cm², NYHA I–II) undergoing cardiac magnetic resonance (CMR)
- Participants
- 457 patients
- Exposure
- Higher vs lower ECV% by CMR
- Eventsn = 83
- Outcome
- Composite of:
- Mortality
- HF admission
- Follow-up
- Median 5.7 years
Methodological detailsinternational, multicentre
- International
- Multicentre
Main finding
As reported in the abstract
median 5.7 years
- Patients with events had higher ECV% (median ECV% 26.3% vs 28.2%)
- P = 0.003
- ECV% had significant incremental prognostic value over AS severity, cardiac function, comorbidities, AVR and late gadolinium enhancement (LGE)
- P < 0.05
Observational data: associations, not effects.
Further findings
Baseline CMR fibrosis measures
- Median ECV% (IQR 24.4%-29.9%)
- 26.6%
- LGE present
- 31.5%
- LGE median extent (IQR 0.1%-1.7%)
- 0.8%
- Greater AS severity associated with greater LV mass and diastolic dysfunction, but not with ECV% or LGE
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diffuse Interstitial Fibrosis of the Myocardium Predicts Outcome in Moderate and Asymptomatic Severe Aortic Stenosis. JACC Cardiovasc Imaging. Published 25 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →