Valvular & structural heart diseaseCohort study
Mismatch Between Residual Mitral Regurgitation and Left Atrial Pressure Predicts Prognosis After Transcatheter Edge-to-Edge Repair
- Prospective multicentre registry study
Authors' conclusion
Post-TEER hemodynamic mismatch between residual MR and postprocedural LAP was associated with a poor prognosis. Six readily accessible perioperative parameters predict the hemodynamic mismatch.
Study context
- Population
- Patients with HF due to severe mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER)OCEAN-Mitral registry
- Participants
- 1,477 patients
- Exposure
- Mismatched and poor vs optimal post-TEER haemodynamics
- Optimaln = 927reference
- Mismatchedn = 459
- Poorn = 91
- Outcome
- Composite of:
- All-cause mortality
- HF hospitalization
Main finding
As reported in the abstract
All-cause mortality and HF hospitalization
Each group vs optimalHazard ratio (95% CI)
Mismatched
1.55(1.28–1.88)
Poor
1.95(1.38–2.74)
Observational data: associations, not effects.
Further findings
Predictors of haemodynamic mismatch after TEER
- 6 predictors: BMI, baseline left atrial volume index, AF, TAPSE, preprocedural mean left atrial pressure (LAP), postprocedural mean mitral valve pressure gradient
Original publication
Mismatch Between Residual Mitral Regurgitation and Left Atrial Pressure Predicts Prognosis After Transcatheter Edge-to-Edge Repair. JACC Cardiovasc Interv. Published 23 September 2024. doi:10.1016/j.jcin.2024.07.046
Summarised from the published abstract; every number is checked against it