Direct Comparison of 67Ga-Scintigraphy and Fluorodeoxyglucose Positron Emission Tomography for the Evaluation of Cardiac Sarcoidosis
Authors' conclusion
67Ga scintigraphy demonstrates lower sensitivity for detecting myocardial inflammation in CS than FDG-PET and has limited prognostic significance.
Study context
- Population
- Patients with cardiac sarcoidosis who underwent both 67Ga scintigraphy and FDG-PET before immunosuppressive drug administrationof 512 in registry
- Participants
- 101 patients
- Exposure
- 67Ga scintigraphy vs FDG-PET
- Both-positiven = 26
- Only FDG-PET-positiven = 72reference
- Only 67Ga scintigraphy-positiven = 0
- Both-negativen = 3
- Outcome
- Positivity by examination findings
Methodological detailsregistry-based (ILLUMINATE-CS)
- Registry-based (ILLUMINATE-CS)
Main finding
As reported in the abstract
- FDG-PET-positive patients with uptake on 67Ga scintigraphy
- 26 (26.5%)
- Segments with 67Ga uptake also positive on FDG-PET
- 94.0%
Observational data: associations, not effects.
Further findings
Composite of all-cause death, HF hospitalization and fatal ventricular arrhythmia · median follow-up 2.9 (1.4-5.3) years
- No significant difference between Both-positive and Only FDG-PET-positive
Original publication
Direct Comparison of 67Ga-Scintigraphy and Fluorodeoxyglucose Positron Emission Tomography for the Evaluation of Cardiac Sarcoidosis. JACC Adv. Published 19 November 2025. doi:10.
Summarised from the published abstract; every number is checked against it