Disease-specific therapy for the treatment of the cardiovascular manifestations of Fabry disease: a systematic review
Authors' conclusion
It remains unclear whether disease-specific therapy sufficiently impacts the cardiovascular manifestations of Fabry disease.
Study context
- Population
- Patients with cardiovascular manifestations of Fabry disease72 studies
- Comparison
- Disease-specific therapy vs placebo or no intervention
- Outcome
- Clinical CV events
Methodological details72 studies: 7 randomised, 16 non-randomised with comparator, 49 non-randomised without comparator, Randomised studies not at serious risk of bias; others at serious risk
- 72 studies: 7 randomised, 16 non-randomised with comparator, 49 non-randomised without comparator
- Randomised studies not at serious risk of bias; others at serious risk
Pooled result
As reported in the abstract
- Studies highly heterogeneous in design, outcome measurements and findings; effectiveness difficult to assess
Original publication
Disease-specific therapy for the treatment of the cardiovascular manifestations of Fabry disease: a systematic review. Heart. Published 28 August 2023. doi:10.
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