Serum Angiotensin-Converting Enzyme Levels Indicating Early Sarcoidosis Diagnosis and Immunosuppressive Therapy Efficacy
Authors' conclusion
In patients with sarcoidosis, ACE levels decreased after the initiation of immunosuppression therapy.
Study context
- Population
- Patients with serum angiotensin-converting enzyme (ACE) measured for suspected sarcoidosis, 2009–2020, single institution215 with sarcoidosis
- Participants
- 3,304 patients
- Comparison
- New serum ACE cut-off vs current cut-off
- Outcome
- Best serum ACE cut-off for detecting sarcoidosis
Methodological detailsretrospective, single institution
- Retrospective
- Single institution
Performance
As reported in the abstract
Diagnostic performance for sarcoidosis
| Strategy | AUC | Sensitivity | Specificity |
|---|---|---|---|
| New cut-off | 0.865 | 78.1 | 81.7 |
| Current cut-off | — not stated in the abstract | 42.3 | 98.6 |
AUC
New cut-off0.865
Current cut-off— not stated in the abstract
Sensitivity
New cut-off78.1
Current cut-off42.3
Specificity
New cut-off81.7
Current cut-off98.6
— not stated in the abstract
Further findings
| Outcome | Sarcoidosis | No sarcoidosis | P value |
|---|---|---|---|
| Serum ACE level, sarcoidosis vs no sarcoidosis | 19.6 (IQR 15.1–31.5) IU/L | 10.7 (IQR 8.4–16.5) | P < 0.01 |
Change in ACE level after immunosuppressive therapy (sarcoidosis)
- ACE decreased more with immunosuppression than without
- P for interaction < 0.01
- ACE decreased in both groups
- P < 0.01
- Interaction P <0.01
Original publication
Serum Angiotensin-Converting Enzyme Levels Indicating Early Sarcoidosis Diagnosis and Immunosuppressive Therapy Efficacy. ESC Heart Fail. Published 9 March 2023. doi:10.
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