Cardio-oncology & otherCohort study
Disproportionate Risk of Cancer Following Diagnosis of Peripheral Artery Disease
- retrospective cohort study
- inverse probability of treatment-weighted Fine-Gray subdistribution hazard model
- MarketScan Research Database (2013-2023)
Authors' conclusion
Patients with PAD experience a higher risk of multiple forms of cancer after controlling for shared risk factors.
Study context
- Population
- Adults aged ≥40 years with ≥36 months of continuous coverage in the MarketScan Research Database (2013–2023)Peripheral arterial disease (PAD) 87,594 · non-PAD CVD 917,680 · without CVD 4,303,899
- Participants
- 87,594 / 917,680 / 4,303,899
- Exposure
- PAD vs non-PAD CVD and vs no CVD
- PADn = 87,594
- non-PAD CVDn = 917,680
- no CVDn = 4,303,899
- Outcome
- time to incident cancer
Main finding
As reported in the abstract
Subdistribution hazard ratio (95% CI)P value
PAD vs non-PAD CVD
1.027(1.001–1.053)
P = 0.044PAD vs no CVD
1.158(1.129–1.187)
P < 0.0001Observational data: associations, not effects.
Further findings
20 most common cancers (individual analysis)
- associations of PAD with specific malignancies
Original publication
Disproportionate Risk of Cancer Following Diagnosis of Peripheral Artery Disease. JACC Adv. Published 15 June 2026. doi:10.1016/j.jacadv.2026.102889
Summarised from the published abstract; every number is checked against it