Early Pregnancy Blood Pressure Trajectory Groups Predict Hypertensive Disorders of Pregnancy
Authors' conclusion
BP trajectories, based on early pregnancy BP measurements, improved ability to predict HDP diagnosis in diverse pregnant cohorts. BP trajectories may improve identification of high-risk patients for more intensive BP monitoring during pregnancy.
Study context
- Population
- Patients with a singleton delivery from 2012 to 2020 in a large urban academic center, excluding those with pre-existing hypertension or serious medical conditions
- Participants
- 25,879 patients
- Comparison
- Inclusion of trajectories into predictive models compared to clinical risk factors alone
- Outcome
- HDP diagnosis, including preeclampsia and gestational hypertension
Methodological detailsElectronic health record data, large urban academic center, Multivariable logistic regression, C-statistics
- Electronic health record data
- Large urban academic center
- Multivariable logistic regression
- C-statistics
Main finding
As reported in the abstract
Diagnosed with hypertensive disorders of pregnancy (HDP)
5,694
21.9%
Adjusted odds of HDP diagnosis across trajectories, lowest
1.6
95% CI 1.4–1.8
Adjusted odds of HDP diagnosis across trajectories, highest
6
95% CI 5.3–6.9
Further findings
C-statistic
| Outcome | Models including trajectories | Clinical risk factors alone |
|---|---|---|
| Predictive model discrimination (C-statistic) | 0.71 (95% CI 0.70–0.72) | 0.66 (95% CI 0.65–0.67) |
Original publication
Early Pregnancy Blood Pressure Trajectory Groups Predict Hypertensive Disorders of Pregnancy. JACC Adv. Published 13 June 2026. doi:10.
Summarised from the published abstract; every number is checked against it