Heart failure & cardiomyopathies
Distinguishing Heart Failure with Reduced Ejection Fraction from Heart Failure with Preserved Ejection Fraction: A Phenomics Approach
Authors' conclusion
We identified pathophysiological mechanisms related to increased cardiac wall thickness parameters and potentially druggable inflammatory markers from the TNFRSF in HFpEF.
Study context
- Population
- Patients with HF and controls without HF from the Singapore Heart Failure Outcomes and Phenotypes (SHOP) cohort; median age 65 years, 50% women
- Participants
- 217 / 213 / 216
- Exposure
- HFrEF vs HFpEF vs controls without HF
- HFrEFn = 217
- HFpEFn = 213
- Controlsn = 216reference
- Outcome
- Discrimination from controls by protein profiles (92 biomarkers)
Methodological detailssubcohort of the prospective SHOP cohort, age- and sex-matched controls
- Subcohort of the prospective SHOP cohort
- Age- and sex-matched controls
Main finding
As reported in the abstract
| Group | AUC |
|---|---|
| HFrEF | 0.89 |
| HFpEF | 0.94 |
AUC
HFrEF0.89
HFpEF0.94
Observational data: associations, not effects.
Original publication
Distinguishing Heart Failure with Reduced Ejection Fraction from Heart Failure with Preserved Ejection Fraction: A Phenomics Approach. Eur J Heart Fail. Published 4 February 2024. doi:10.
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