Does Down syndrome influence the outcomes of congenital cardiac surgery? A systematic review and meta-analysis
Pooled result · Long-term mortalityResult — go to the resultHazard ratio 0.86 95% CI 0.6–1.23Authors' conclusion
DS does not affect post-congenital cardiac surgical survival in adulthood.
Study context
- Population
- Adults (>18 years) with operated congenital heart disease
- Participants
- 10,466 adults23 studies
- Comparison
- Down syndrome (DS) vs no DS
- Outcome
- Long-term mortality
- Follow-up
- Maximum 38 years
Methodological detailsrandom- and fixed-effects models, Risk of bias frequently high (unblinded retrospective designs, limited adjustment)
- Random- and fixed-effects models
- Risk of bias frequently high (unblinded retrospective designs, limited adjustment)
Pooled result
As reported in the abstract
Hazard ratio
0.86
95% CI 0.6–1.23
DSvs Without DS
HR 0.86 (95% CI 0.6–1.23)
Further pooled results
| Outcome | HR (95% CI) | |
|---|---|---|
| Cardiac reoperation | 0.6 (0.46–0.78) | |
| 0.512Hazard ratio (log scale) |
Original publication
Does Down syndrome influence the outcomes of congenital cardiac surgery? A systematic review and meta-analysis. Eur Heart J Qual Care Clin Outcomes. Published 24 May 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →