Pulmonary vascular disease & thromboembolism
Does veno-arterial carbon dioxide gradient provide an adequate estimation of cardiac index in pulmonary hypertension?
Authors' conclusion
Veno-arterial carbon dioxide gradient moderately correlates with Fick CI and may be useful to identify patients with low CI.
Study context
- Population
- Patients with pulmonary hypertension (PH) (all haemodynamic types) undergoing direct Fick CI measurement during right heart catheterizationprospective cohort n = 32
- Participants
- 186 patients
- Exposure
- PvaCO2 vs direct Fick CI
- Outcome
- Correlation between PvaCO2 and direct Fick CI
Methodological detailssingle-centre, separate prospective cohort
- Single-centre
- Separate prospective cohort
Main finding
As reported in the abstract
Correlation of PvaCO2 with Fick CI
PvaCO2 moderately correlated with Fick CI, R
−0.51
95% CI −0.61, −0.39
Observational data: associations, not effects.
Further findings
CI < 2.5 L/min/m² with higher PvaCO2
| OR (95% CI) | ||
|---|---|---|
| Higher PvaCO2 | 1.88 (1.55–2.35) | |
| 0.512Odds ratio (log scale) |
| Outcome | Mean difference (95% CI) | |
|---|---|---|
| Central vs mixed venous CO2 agreement (prospective cohort, n = 32)Central overestimated mixed venous values | 3.3 (2.5–4.0) | |
| −20246Difference (linear scale) |
- Central vs mixed venous CO2 agreement (prospective cohort, n = 32) — Poor agreement overall; limits of agreement
- −1.10, 7.59
Thermodilution vs Fick CI
- Low thermodilution CI with normal PvaCO2 associated with thermodilution underestimation of Fick CI
Original publication
Does veno-arterial carbon dioxide gradient provide an adequate estimation of cardiac index in pulmonary hypertension? Eur Heart J Acute Cardiovasc Care. Published 27 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →