Door-to-diuretic time and mortality in patients with acute heart failure: A systematic review and meta-analysis

Sampaio Rodrigues, T; Garcia Quarto, LJ; Nogueira, SC; Theuerle, JD; Farouque, O; Burrell, LM; Koshy, AN

doi:10.1016/j.ahj.2023.12.012

Heart failure & cardiomyopathies

Door-to-diuretic time and mortality in patients with acute heart failure: A systematic review and meta-analysis

Am Heart JPublished March 2024Systematic review and meta-analysis of observational studies

Pooled result · 30-day mortalityResultOdds ratio 0.77 95% CI 0.64–0.93

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Study context

Population: Patients with acute HF
Participants: 28,124 patients

Comparison: Early vs later door-to-IV diuretic time
Outcome: Mortality
Follow-up: 30 days

Pooled result

30-day mortality

Odds ratio

0.77

95% CI 0.64–0.93

Early IV diuresisvs Later IV diuresis

OR 0.77 (95% CI 0.64–0.93)

As reported in the abstract

Further pooled results

Outcome	← Lower odds with early IV diuresis ←→ Higher odds with early IV diuresis →	OR (95% CI)
In-hospital deathEarly IV diuresisvs Later IV diuresisNo significant reduction	0.512	0.84 (0.57–1.24)
	0.512Odds ratio (log scale)

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Door-to-diuretic time and mortality in patients with acute heart failure: A systematic review and meta-analysis. Am Heart J. Published March 2024. doi:10.1016/j.ahj.2023.12.012

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