Heart failure & cardiomyopathies
DPD Quantification Correlates With Extracellular Volume and Disease Severity in Wild-Type Transthyretin Cardiac Amyloidosis
Authors' conclusion
In ATTRwt-CM, quantitative cardiac DPD uptake correlates with myocardial amyloid load, longitudinal cardiac function, cardiac biomarkers, exercise capacity, and disease stage, providing a valuable tool to quantify and monitor cardiac disease burden.
Study context
- Population
- Patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM)
- Participants
- 40 patients
- Exposure
- High vs low cardiac DPD uptake
- Low uptaken = 20reference
- High uptaken = 20
- Outcome
- Associations of quantitative DPD SPECT/CT SUV retention index with myocardial amyloid burden (ECV), cardiac function, biomarkers and clinical status
Main finding
As reported in the abstract
Univariable linear regression of SUV retention index
- Extracellular volume (ECV)
- r = 0.669, β = 0.139, P < 0.001
- Native T1 time
- r = 0.432, β = 0.020, P = 0.005
- RV-LS
- r = 0.445, β = 0.204, P = 0.004
- NT-proBNP (log10)
- r = 0.458, β = 2.842, P = 0.003
- Troponin T
- r = 0.422, β = 0.048, P = 0.007
- 6MWD
- r = 0.385, β = −0.007, P = 0.017
- NAC stage
- r = 0.490, β = 1.785, P = 0.001
Observational data: associations, not effects.
Further findings
High vs low uptake cohort comparison
- ECV differed
- P = 0.001
- Native T1 time differed
- P = 0.013
- RV-LS differed
- P = 0.003
- NT-proBNP differed
- P < 0.001
- Troponin T differed
- P = 0.046
- 6MWD differed
- P = 0.002
- NAC stage differed
- I: P < 0.001, II: P = 0.030, III: P = 0.021
- Mann-Whitney U or chi-squared test
Original publication
DPD Quantification Correlates With Extracellular Volume and Disease Severity in Wild-Type Transthyretin Cardiac Amyloidosis. JACC Adv. Published 12 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it