Arrhythmias & electrophysiology
Durability of CLOSE-Guided Pulmonary Vein Isolation in Persistent Atrial Fibrillation: A Prospective Remapping Study
Authors' conclusion
In patients with persistent AF, CLOSE-guided PVI resulted in durable rate of PVI on a per-vein and per-patient level of 76% and 58%, respectively. Arrhythmia recurrence was numerically higher in patients with durable PVI compared with patients without.
Study context
- Population
- Patients with symptomatic, persistent atrial fibrillation (AF) undergoing CLOSE-guided pulmonary vein isolation (PVI)26 underwent remapping
- Participants
- 30 patients
- Outcome
- Lesion durability (PV reconnections) at planned remapping procedure
- Follow-up
- 6 months after index procedure
Methodological detailsmandated remapping procedure at 6 months, 4 patients without recurrence refused repeat procedure
- Mandated remapping procedure at 6 months
- 4 patients without recurrence refused repeat procedure
Main finding
As reported in the abstract
Pulmonary vein (PVs) with durable isolation (per vein)
78 of 102
76%
Patients with complete isolation of all PVs (per patient)
15
58%
Observational data: associations, not effects.
Further findings
Arrhythmia recurrence by PV isolation status
P = 0.197
Arrhythmia recurrence before redo procedure (beyond blanking period)
- Patients with arrhythmia recurrence
- 6 of 26 (23%)
Freedom from arrhythmia after re-PVI or additional ablation · 12 months
- Patients free of arrhythmia
- 17 of 26 (65%)
Original publication
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