Heart failure & cardiomyopathies
Dynamic Changes of Distinct Compartmental LV Remodeling Following Septal Myectomy in Hypertrophic Obstructive Cardiomyopathy
Authors' conclusion
In patients with hypertrophic obstructive cardiomyopathy postseptal myectomy, early LVMi reduction involves both cellular and extracellular compartments, with slower reduction from 12 to 24 months, mainly driven by the extracellular component.
Study context
- Population
- Patients with hypertrophic obstructive cardiomyopathy undergoing septal myectomy17 female
- Participants
- 27 patients
- Outcome
- LVMi regression (with indexed cellular and extracellular volume) on CMR
- Follow-up
- 6, 12 and 24 months postoperatively
Methodological detailsserial CMR (preoperative, 6, 12, 24 months)
- Serial CMR (preoperative, 6, 12, 24 months)
Main finding
As reported in the abstract
LVMi
- Left ventricular mass index (LVMi) preoperatively
- 105.76±25.22 g/m²
- LVMi at 6 months
- 82.52±25.90 g/m²
- LVMi at 12 months
- 78.86±24.73 g/m²
- LVMi at 24 months
- 76.22±23.93 g/m²
- Significant decrease in LVMi
- P<0.05
- Mean % decrease in LVMi from baseline at 6 months
- 22.97%
- Mean % decrease in LVMi from baseline at 12 months
- 26.26%
- Mean % decrease in LVMi from baseline at 24 months
- 28.58%
Observational data: associations, not effects.
Further findings
Compartmental remodeling (indexed cellular and extracellular volume)
- Indexed cellular volume regression, first 6 months
- 23.70%
- Indexed extracellular volume reduction, first 6 months
- 18.40%
- 12 to 24 months: only indexed extracellular volume continued to decline (22.13±6.76 to 20.89±6.25 mL/m²)
- P < 0.001
- Both compartments: sustained reductions through 12 months
Factors associated with LVMi regression (linear regression)
- Greater LV outflow tract pressure gradient reduction, β=0.157
- P = 0.001
Original publication
Dynamic Changes of Distinct Compartmental LV Remodeling Following Septal Myectomy in Hypertrophic Obstructive Cardiomyopathy. Circ Cardiovasc Imaging. Published 27 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →