Heart failure & cardiomyopathies
Sodium Loading in Ambulatory Patients with Heart Failure with Reduced Ejection Fraction: Mechanistic Insights Into Sodium Handling
Authors' conclusion
Selected HFrEF patients can tolerate sodium loading, with increased renal sodium excretion and decreased neurohormonal activation.
Study context
- Population
- Ambulatory, stable patients with heart failure with reduced ejection fraction (HFrEF) and healthy controls
- Participants
- 21 vs 10
- Comparison
- Sodium loading in HFrEF patients and healthy controls
- HFrEFn = 21
- Healthy controlsn = 10reference
- Outcome
- Effects of sodium loading in HFrEF
- Follow-up
- After 4-week sodium loading
Methodological details2-week run-in, then 4-week daily sodium increment; clinical, echo, 24-h urine and bioimpedance data every 2 weeks
- 2-week run-in, then 4-week daily sodium increment; clinical, echo, 24-h urine and bioimpedance data every 2 weeks
Main finding
As reported in the abstract
- No significant effect on weight, BP, congestion score, NT-proBNP, echocardiographic congestion indices or total body water
- all p > 0.09
- Total blood volume unchanged: 4748 ml vs. 4885 ml
- p = 0.327
- Natriuresis increased from 150 mmol/24 h to 173 mmol/24 h
- p = 0.024
- Plasma renin decreased from 286 to 88 μU/L
- p = 0.002
- No significant changes in skin sodium, total GAG or sulfated GAG content
- all p > 0.265
Further findings
Healthy controls response to sodium loading
- No change in volume status; higher increase in natriuresis than HFrEF without any change in renin
Original publication
Sodium Loading in Ambulatory Patients with Heart Failure with Reduced Ejection Fraction: Mechanistic Insights Into Sodium Handling. Eur J Heart Fail. Published 21 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →