Heart failure & cardiomyopathies
Global Longitudinal Strain Predicts Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction
Authors' conclusion
In patients with HFpEF, abnormal GLS is common and is a strong predictor for clinical events and future deterioration in LVEF.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF)
- Participants
- 311 patients
- Exposure
- Abnormal global longitudinal strain (GLS) vs normal GLS
- Abnormal GLSn = 183
- Normal GLSn = 128reference
- Outcome
- Composite of:
- CV mortality or HF hospitalization
- Deterioration in LVEF to <40%
- Follow-up
- Median 4.6 years
Main finding
As reported in the abstract
Abnormal GLS
- Composite outcome
- 62%
- Left ventricular ejection fraction (LVEF) deterioration
- 19%
Normal GLS
- Composite outcome
- 44%
- LVEF deterioration
- 10%
Composite outcome
Abnormal GLS62%
Normal GLS44%
Left ventricular ejection fraction (LVEF) deterioration
Abnormal GLS19%
Normal GLS10%
Abnormal GLS vs Normal GLSHazard ratio (95% CI)P value
Composite of CV mortality or HF hospitalization
1.74(1.3–2.4)
P < 0.001Deterioration in LVEF
2.2(1.2–4.3)
P = 0.018Observational data: associations, not effects.
Further findings
GLS as continuous variable
- Each 1% increase in GLS: increased odds for composite outcome
- 10%
- Each 1% increase in GLS: increased odds for deterioration in LVEF
- 13%
Original publication
Global Longitudinal Strain Predicts Clinical Outcomes in Patients with Heart Failure with Preserved Ejection Fraction. Eur J Heart Fail. Published 24 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →