Arrhythmias & electrophysiology
Early versus delayed catheter ablation in atrial fibrillation and heart failure: A systematic review and meta-analysis
Authors' conclusion
Evidence from pooled observational studies suggests early CA is associated with reduced AF recurrence and HF hospitalization in patients with AF and HF; a mortality benefit was not statistically confirmed.
Study context
- Population
- Adults with atrial fibrillation (AF) and heart failure (HF)
- Participants
- 15,822 adults10 studies
- Comparison
- Early vs delayed catheter ablation
- Outcome
- AF recurrence, all-cause mortality and HF hospitalizations
Methodological detailsrandom-effects, Narrative synthesis included 2 additional RCTs comparing treatment strategies
- Random-effects
- Narrative synthesis included 2 additional RCTs comparing treatment strategies
Pooled result
As reported in the abstract
AF recurrence, all-cause mortality, HF hospitalization
Early CA vs Delayed CAHazard ratio (95% CI)P value
AF recurrence; k = 8; I2 = 67.6%
0.63(0.52–0.78)
P < 0.0001HF hospitalization; k = 5; I2 = 0%
0.63(0.51–0.77)
P < 0.0001- Nonsignificant trend toward reduced all-cause mortality (k = 4, I2 = 75.3%)
- HR 0.71, 95% CI 0.41-1.24, P = .23
Original publication
Early versus delayed catheter ablation in atrial fibrillation and heart failure: A systematic review and meta-analysis. Heart Rhythm. Published 17 June 2025. doi:10.
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