Valvular & structural heart disease
Echocardiographic cardiac damage classification and clinical outcomes in atrial functional mitral regurgitation
Main finding · Composite of all-cause death, heart failure hospitalisations and mitral valve (MV) interventionsResult — go to the resultHazard ratio 1.65 95% CI 1.29–2.11Authors' conclusion
A cardiac damage classification system based on echocardiographic parameters provides prognostic insights in patients with AFMR, identifying subgroups at higher risk of adverse outcomes. Future studies are needed to validate its use in guiding therapeutic decisions.
Study context
- Population
- Patients with moderate or severe atrial functional mitral regurgitation (AFMR)patients with AFMR
- Participants
- 1,007 patients
- Exposure
- Echocardiographic cardiac damage classification groups 1-4
- Outcome
- Composite of:
- All-cause death
- Heart failure hospitalisations
- Mitral valve (MV) interventions
- Follow-up
- Median 3.0 years
Main finding
As reported in the abstract
Hazard ratio
1.65
95% CI 1.29–2.11
P < 0.001
By group
Group 4vs group 1
HR 1.65 (95% CI 1.29–2.11); P < 0.001
Observational data: associations, not effects.
Further findings
Individual components of the composite endpoint
- Classification consistently stratified risks for individual components, particularly in patients without mitral valve (MV) intervention
Cohort characteristics
- Mean age
- 78±10 years
- Female
- 56%
Original publication
Echocardiographic cardiac damage classification and clinical outcomes in atrial functional mitral regurgitation. Heart. Published 6 February 2025. doi:10.
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