Heart failure & cardiomyopathies
Echocardiographic Features Beyond Ejection Fraction and Associated Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction
Main finding · All-cause mortality (multivariable model)Result — go to the resultHazard ratio 1.35 95% CI 1.11–1.63Authors' conclusion
In a large, real-world HF with mildly reduced or preserved LVEF population, echocardiographic features, led by LV GLS, were associated with adverse outcomes irrespective of LVEF.
Study context
- Population
- Patients with heart failure (HF) with mildly reduced or preserved left ventricular ejection fraction (LVEF) in a large US health care system, echo 2017–2020complete echo data
- Participants
- 2,337 patients
- Exposure
- Echocardiographic features beyond LVEF
- Outcome
- All-cause mortality
- Follow-up
- 3 years
Methodological detailsmultivariable model, stepwise selection
- Multivariable model
- Stepwise selection
Main finding
All-cause mortality (multivariable model) · 3 years
Hazard ratio
1.35
95% CI 1.11–1.63
P = 0.002
Abnormal LV GLSvs Normal LV GLS
HR 1.35 (95% CI 1.11–1.63); P = 0.002
As reported in the abstract
- Univariate: E/e´+e´, LV GLS, LA volume index associated with all-cause mortality
- all P<0.01
Observational data: associations, not effects.
Further findings
- Abnormal LV GLS among patients with LVEF>55%
- 40% · 498 events
- Abnormal LV GLS among patients with LVEF>55%: 498/1255
Comorbidities and event rates, abnormal vs normal LV GLS
- Regardless of LVEF, abnormal LV GLS had higher burden of multiple comorbidities and higher event rates
Original publication
Echocardiographic Features Beyond Ejection Fraction and Associated Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction. Circ Heart Fail. Published 16 May 2023. doi:10.
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