Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome
Authors' conclusion
In overweight or obese people with Mets, an ILI had no impact on the underlying structural and functional LA substrate measurements associated with AF risk.
Study context
- Population
- Overweight or obese people with metabolic syndrome (echocardiography subsample; mean age 65 years, 40% women)trial n = 6874
- Participants
- 534 participants
- Comparison
- Intensive lifestyle intervention (ILI) vs control intervention
- Primary endpoint
- LA structure and function (LA emptying fraction, LA longitudinal strain)
- Follow-up
- 5 years
Methodological detailscore echocardiography lab, mixed models
- Core echocardiography lab
- Mixed models
Primary result
As reported in the abstract
| Group | Left atrial (LA) emptying fraction | LA longitudinal strain |
|---|---|---|
| Control | −0.95% (95% CI −0.93, −0.98) | 0.82% (95% CI 0.79, 0.85) |
| ILI | −0.97% (95% CI −0.94, −1.00) | 0.85% (95% CI 0.82, 0.89) |
Left atrial (LA) emptying fraction
Control−0.95% (95% CI −0.93, −0.98)
ILI−0.97% (95% CI −0.94, −1.00)
LA longitudinal strain
Control0.82% (95% CI 0.79, 0.85)
ILI0.85% (95% CI 0.82, 0.89)
- ILI vs Control: Pbetween groups = 0.80 — LA emptying fraction
- ILI vs Control: Pbetween groups = 0.24 — LA longitudinal strain
Secondary outcomes
Mean, kg
| Outcome | ILI | Control |
|---|---|---|
| Weight change · 5 years | −3.9 (SD 5.3 kg) | −0.3 (SD 5.1 kg) |
Secondary LA outcomes
- No significant difference between groups for any secondary outcome
Original publication
Effect of an intensive lifestyle intervention on the structural and functional substrate for atrial fibrillation in people with metabolic syndrome. Eur J Prev Cardiol. Published 15 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →