Heart failure & cardiomyopathies
Effect of Blood Pressure Index on Clinical Outcomes in Patients with Heart Failure and Chronic Kidney Disease
Authors' conclusion
The baseline SBP and DBP CV may remain significant for clinical outcomes in patients with both HF and CKD.
Study context
- Population
- Patients with both heart failure (HF) and chronic kidney disease (CKD) from the Chronic Renal Insufficiency Cohort (CRIC) studyof 3939 CRIC participants
- Participants
- 382 patients
- Comparison
- Blood pressure (BP) index and clinical outcomes
- Primary endpoint
- Composite of:
- CVD events
- Renal events
- All-cause death
Primary result
As reported in the abstract
Primary endpoint
Hazard ratio (95% CI)P value
Baseline SBP
1.22(1.03–1.44)
P = 0.02DBP CV
1.03(1.01–1.06)
P = 0.02Further findings
Renal events
| HR (95% CI) | P value | ||
|---|---|---|---|
| Baseline SBPAdjusted Cox regression | 1.54 (1.22–1.95) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
Cardiovascular disease (CVD) events
| HR (95% CI) | P value | ||
|---|---|---|---|
| DBP CVAdjusted Cox regression | 1.04 (1.02–1.07) | P < 0.01 | |
| 0.512Hazard ratio (log scale) |
Linear associations (forest plot)
- Baseline systolic BP (SBP) linear association with CVD and renal events
- P = 0.04 and 0.001, respectively
- DBP CV linear association with CVD events
- P = 0.02
Nonlinear associations of DBP CV (restricted cubic spline)
- J- or L-curved association with primary endpoint, renal events and all-cause death (P for nonlinearity)
- 0.01, <0.001, and 0.01, respectively
Original publication
Effect of Blood Pressure Index on Clinical Outcomes in Patients with Heart Failure and Chronic Kidney Disease. ESC Heart Fail. Published 4 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →