Acute cardiac care & resuscitation
Effect of Microaxial Flow Pump on Hemodynamics in STEMI-Related Cardiogenic Shock
Authors' conclusion
The mAFP reduces intrinsic mechanical work of the heart in STEMI-CS patients enrolled in the DanGer shock trial by reducing native CO, pulmonary pressures, and LV filling pressures while maintaining hydraulic power output delivered to the body by the heart and mAFP (CPO).
Study context
- Population
- Patients with STEMI-related cardiogenic shock monitored with a pulmonary artery catheterof 324 admitted to cardiac intensive care unit (CICU)
- Participants
- 223 patients
- Comparison
- Microaxial flow pump (mAFP) vs standard of care
- mAFPn = 125
- Standard of caren = 98reference
- Primary endpoint
- CO, CPO and mean PAP
- Follow-up
- First 48 hours
Primary result
As reported in the abstract
First measured hemodynamics after CICU admission (CO, mean PAP, CPO) · first measurement; followed to 48 hours
| Group | Value | Cardiac output (CO) (median, Q1-Q3; reported as control) | Cardiac power output (CPO) (median, 95% CI; reported as control) | CO (median, Q1-Q3) | CPO (median, 95% CI) |
|---|---|---|---|---|---|
| Standard of care | median 31 (IQR 29–39) mm Hg | 3.4 L/min (2.6-4.4 L/min) | 0.56 W (0.41-0.76 W) | ||
| mAFP | median 27 (IQR 23–33) mm Hg | 3.7 L/min (3.2-4.5 L/min) | 0.68 W (0.51-0.85 W) |
Value
Standard of caremedian 31 (IQR 29–39) mm Hg
mAFPmedian 27 (IQR 23–33) mm Hg
Cardiac output (CO) (median, Q1-Q3; reported as control)
Standard of care3.4 L/min (2.6-4.4 L/min)
mAFPNot reported in the abstract
Cardiac power output (CPO) (median, 95% CI; reported as control)
Standard of care0.56 W (0.41-0.76 W)
mAFPNot reported in the abstract
CO (median, Q1-Q3)
Standard of careNot reported in the abstract
mAFP3.7 L/min (3.2-4.5 L/min)
CPO (median, 95% CI)
Standard of careNot reported in the abstract
mAFP0.68 W (0.51-0.85 W)
- mAFP vs Standard of care: P < 0.001 — first mean pulmonary artery pressure (PAP)
- mAFP vs Standard of care: P = 0.13 — first CO
- mAFP vs Standard of care: P = 0.01 — first CPO
Further findings
First measured PCWP · remained lower until 48 h
P < 0.001
Original publication
Effect of Microaxial Flow Pump on Hemodynamics in STEMI-Related Cardiogenic Shock. J Am Coll Cardiol. Published 1 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it