Acute cardiac care & resuscitation
Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock: A Post Hoc Analysis of the Danish-German (DanGer) Shock Randomized Clinical Trial
Authors' conclusion
Randomization SBP was associated with the survival benefit of microaxial flow pump treatment, with the most hypotensive patients deriving the largest survival benefit.
Study context
- Population
- Adults with STEMI complicated by cardiogenic shock, 14 tertiary cardiac centres in Denmark, Germany and the UK, 2013–2023of 355 in trial
- Participants
- 351 adults
- Comparison
- Microaxial flow pump vs Standard care
- Primary endpoint
- All-cause mortality according to randomization SBP
- Follow-up
- 180 days
Methodological detailspost hoc analysis, open-label, multicentre
- Post hoc analysis
- Open-label
- Multicentre
Primary result
As reported in the abstract
All-cause mortality by randomization SBP (subgroups)
Microaxial flow pump vs Standard careOdds ratio (95% CI)P value
SBP lower than 82 mm Hg
0.34(0.18–0.63)
P < 0.001Higher SBP
0.96(0.53–1.70)
P = 0.90Further findings
Kaplan-Meier survival and spline regression analyses
- Supported the findings; P for interaction
- P = 0.02
- P for nonlinearity
- P = 0.01
Original publication
Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock: A Post Hoc Analysis of the DanGer Shock Randomized Clinical Trial. JAMA Cardiol. Published 1 November 2025. doi:10.
Summarised from the published abstract; every number is checked against it