Heart failure & cardiomyopathies
Effect of Sex on Sodium-Glucose Co-Transporter-2 Antagonists and Glucagon-Like Peptide-1 Agonists in Heart Failure
Authors' conclusion
SGLT-2 antagonists but not GLP-1 agonists beneficially affect HFH and CV death in patients with HF with or without diabetes.
Study context
- Population
- Adults with heart failure (HF) in randomized controlled trials (RCTs) of SGLT2 antagonists or GLP-1 agonists
- Participants
- 24,781 adults6 RCTs
- Comparison
- SGLT2 antagonists or GLP-1 agonists vs control
- Outcome
- HF hospitalization (HFH) or CV death, and effect of biological sex
Methodological detailsrandom effects model, sex subgroup analyses, 4 studies SGLT-2 antagonists, 2 studies GLP-1 agonists, Searched MEDLINE, Embase, Cochrane Library and trial databases until February 2023
- Random effects model
- Sex subgroup analyses
- 4 studies SGLT-2 antagonists, 2 studies GLP-1 agonists
- Searched MEDLINE, Embase, Cochrane Library and trial databases until February 2023
Pooled result
As reported in the abstract
SGLT-2 antagonistsOdds ratio (95% CI)P value
HFH, men
0.70(0.64–0.76)
P < 0.001HFH, women
0.58(0.46–0.74)
P < 0.001CV death, men
0.86(0.78–0.95)
P = 0.003CV death, women
0.84(0.73–0.96)
P = 0.01- GLP-1 agonists: neutral effect on HF hospitalization (HFH) and cardiovascular (CV) death, similar in men and women
- all P > 0.05
Further pooled results
HFH and CV death, overall
| OR (95% CI) | P value | ||
|---|---|---|---|
| SGLT-2 antagonistsHFH | 0.69 (0.63–0.77) | P < 0.001 | |
| SGLT-2 antagonistsCV death | 0.87 (0.78–0.97) | P = 0.01 | |
| 0.512Odds ratio (log scale) |
- HFH and CV death, overall: independent of diabetes status; excellent homogeneity across 4 SGLT-2 studies
HFH and CV death, overall
- No beneficial effects found for GLP-1 agonists
Original publication
Effect of Sex on Sodium-Glucose Co-Transporter-2 Antagonists and Glucagon-Like Peptide-1 Agonists in Heart Failure. ESC Heart Fail. Published 23 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →