Arrhythmias & electrophysiology
Effectiveness and safety of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation at low risk of stroke in japan: a retrospective cohort study
Authors' conclusion
Non-vitamin K antagonist oral anticoagulants treatment may be associated with a slightly high risk of ICH, and it yielded a neutral clinical benefit in the present Japanese population
Study context
- Population
- Patients with atrial fibrillation (AF) at low risk of stroke, JMDC Claims Database (Japan), April 2011–November 2022
- Participants
- 13,291 patients
- Exposure
- NOAC vs no treatment
- Outcome
- Stroke, ICH and net clinical benefit
Methodological detailsinverse probability of treatment weighting
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
Nontreatment
- Stroke
- 0.47 per 100 person-years
- Intracranial haemorrhage (ICH)
- 0.15 per 100 person-years
Nontreatment
Stroke0.47 per 100 person-years
Intracranial haemorrhage (ICH)0.15 per 100 person-years
NOAC vs NontreatmentHazard ratio (95% CI)
Stroke
1.41(0.84–2.36)
- Stroke, ICH and net clinical benefit
- net clinical benefit −0.35 % per year (95% CI −0.99-0.29%)
Observational data: associations, not effects.
Safety
| Outcome | HR (95% CI) | |
|---|---|---|
| ICH | 1.73 (0.75–4.00) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Effectiveness and safety of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation at low risk of stroke in japan: a retrospective cohort study. Eur Heart J Cardiovasc Pharmacother. Published 19 October 2023. doi:10.
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