Arrhythmias & electrophysiology
Effects of body mass index and blood pressure on atrioventricular block: Two-sample mendelian randomization
Authors' conclusion
Elevated BMI, SBP, and DBP exhibited causal effects on AV block. The impacts were partly mediated by CAD.
Study context
- Comparison
- Genetically predicted cardiometabolic traits vs atrioventricular (AV) block risk
- Outcome
- AV block (causal effects of cardiometabolic exposures: BMI, SBP, DBP, fasting glucose, fasting insulin, LDL, HDL, TG)
Methodological detailsmultivariable mendelian randomization, two-step, two-sample mediation analysis
- Multivariable mendelian randomization
- Two-step, two-sample mediation analysis
Main finding
As reported in the abstract
AV block
Odds ratio (95% CI)P value
Genetically predicted elevation of BMI
1.40(1.10–1.78)
P = 0.006Genetically predicted elevation of SBP
1.02(1.00–1.03)
P = 0.015Genetically predicted elevation of DBP
1.04(1.01–1.07)
P = 0.005Further findings
Reverse causation (AV block on traits)
- No reverse causal effects
Multivariable MR, mutually adjusted
- Causal effects of increased body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP) on AV block after mutual adjustment
Proportion of AV block risk mediated by coronary artery disease (CAD)
- From BMI
- 14.20% (8.82%, 16.46%)
- From SBP
- 26.32% (25.00%, 26.47,%)
- From DBP
- 12.20% (7.69%, 15.94%)
Original publication
Effects of body mass index and blood pressure on atrioventricular block: Two-sample mendelian randomization. Heart Rhythm. Published 2 November 2023. doi:10.
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