Arrhythmias & electrophysiology
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study
Authors' conclusion
In contrast with the current observational knowledge of RHR and AF, an inverse causal association between RHR and AF was demonstrated in both linear and non-linear MR for RHR values up to 90 bpm.
Study context
- Population
- Individuals in the Trøndelag Health Study (HUNT) and UK Biobank (UKB)
- Participants
- 69,155 vs 431,852
- Comparison
- Genetically predicted lower resting heart rate (RHR) and atrial fibrillation (AF) risk
- HUNTn = 69,155
- UKBn = 431,852
- Outcome
- Causal association and its shape between RHR and AF
Methodological detailslinear and non-linear Mendelian randomization (MR), individual-level data
- Linear and non-linear MR
- Individual-level data
Main finding
As reported in the abstract
AF per unit decrease in RHR (linear MR)
HUNT
7,062
events
UKB
20 452
events
Odds ratio (95% CI)
HUNT
0.95(0.93–0.98)
UKB
0.96(0.95–0.97)
Per unit decrease in RHR, as printed
Further findings
- Several sensitivity analyses were also consistent
Original publication
Insight into the relationship between resting heart rate and atrial fibrillation: a Mendelian randomization study. Europace. Published 21 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →