Effects of fortified eggs and time-restricted eating on cardiometabolic health: The prosperity trial
Authors' conclusion
These data did not demonstrate clinically relevant differences in changes in LDL and HDL levels over 4 months with FE and TRE compared with nonegg supplemented diet and usual care diet, respectively, providing evidence that adverse short-term lipid and biomarker changes did not occur with FE consumption.
Study context
- Population
- Patients with a prior CV event or 2 CV risk factors
- Participants
- 140 patients
- Comparison
- Fortified eggs vs nonegg supplemented diet; Time-restricted eating (TRE) vs usual care diet
- Primary endpoint
- Co-primary: LDL- and HDL-cholesterol (change from baseline, least squares (LS) means)
- Follow-up
- 4 months
Methodological detailsunblinded, 2-by-2 factorial
- Unblinded
- 2-by-2 factorial
Primary result
As reported in the abstract
Difference in LS means, mg/dL (95% CI)
FEvs Nonegg supplemented dietHDL
−0.64(−3.86 to 2.58)
FEvs Nonegg supplemented dietLDL
−3.14(−10.81 to 4.52)
TREvs Usual care dietHDL
1.51(−1.65 to 4.68)
TREvs Usual care dietLDL
1.17(−6.36 to 8.70)
Secondary outcomes
HDL and LDL with fortified eggs (FE) in patients ≥65 years (prespecified subgroup)
- Nonsignificant HDL increase and LDL decrease with FE
Original publication
Effects of fortified eggs and time-restricted eating on cardiometabolic health: The prosperity trial. Am Heart J. Published 15 October 2024. doi:10.
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