Arrhythmias & electrophysiology
Efficacy and safety of ajmaline in patients with electrical storm
Authors' conclusion
In selected patients with refractory ES, intravenous ajmaline treatment was associated with a reduction in ventricular arrhythmias and a favorable safety profile.
Study context
- Population
- Adults admitted to the ICU with electrical storm (ES) refractory to guideline-recommended care, 2013–2023of 332 with recurrent VT/VF
- Participants
- 46 adults
- Outcome
- Arrhythmia response to ajmaline
Methodological detailssingle-group
- Single-group
Main finding
As reported in the abstract
Complete arrhythmia suppression
34
74%
Partial suppression
2
4%
VT slowing
5
11%
No effect
5
11%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| In-hospital death · During hospitalization | Ajmaline 11% · Multiorgan failure 2 (4%) · Combined septic and cardiogenic shock 3 (7%) |
- In-hospital death: despite complete or partial arrhythmia suppression by ajmaline
In-hospital course and 6-month follow-up
- In-hospital death
- 5 (11%)
- Death from multiorgan failure
- 2 (4%)
- Death from combined septic and cardiogenic shock
- 3 (7%)
- Catheter ablation
- 28 (61%)
- Discharged in stable rhythm
- 41 (89%)
- Alive at 6 months (15 lost to follow-up)
- 24 of 26
Safety
| Outcome | Values |
|---|---|
| Minor adverse events | Ajmaline 7% |
Serious adverse events requiring discontinuation
- Serious adverse events requiring discontinuation were not observed
Original publication
Efficacy and safety of ajmaline in patients with electrical storm. Heart Rhythm. Published 17 December 2025. doi:10.
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