Efficacy and safety of colchicine for the treatment of myopericarditis
Authors' conclusion
In patients with first attack of pericarditis associated with myocardial involvement, colchicine was safe and efficacious for the reduction of recurrences.
Study context
- Population
- Consecutive patients admitted for first attack of pericarditis with myocarditismatched cohort 2 × 73
- Participants
- 175 patients
- Exposure
- Colchicine vs no colchicine
- Outcome
- Time to first recurrence
- Follow-up
- Median 25.3 (IQR 8.3-45.6) months
Methodological detailsdouble-centre, propensity-score matched
- Double-centre
- Propensity-score matched
Main finding
As reported in the abstract
Recurrences
P = 0.001
- Longer event-free survival with colchicine
- P = 0.005
Observational data: associations, not effects.
Further findings
Independent risk factors for recurrences (multivariable)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Women | 1.97 (1.04–3.73) | P = 0.037 | |
| Corticosteroid use | 2.27 (1.15–4.47) | P = 0.018 | |
| 0.20.5125Hazard ratio (log scale) |
Safety
- Colchicine-associated side effects (mild)
- 1.7% · 3 events
Original publication
Efficacy and safety of colchicine for the treatment of myopericarditis. Heart. Published 18 January 2024. doi:10.
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