Heart failure & cardiomyopathies
Efficacy of Guideline-Directed Medical Treatment in Heart Failure with Mildly Reduced Ejection Fraction
Authors' conclusion
In patients with HFmrEF, combined use of neurohormonal antagonists produces remarkable effects in reducing the occurrence of the primary outcome of rehospitalization and death.
Study context
- Population
- Patients with Heart Failure with Mildly Reduced Ejection Fraction (HFmrEF) admitted to The First Affiliated Hospital of Dalian Medical University, 2015–2019matched cohort
- Participants
- 906 patients
- Exposure
- Triple-drug therapy vs non-triple therapy
- TTn = 302
- Non-triple therapy (NTT)n = 604reference
- Outcome
- All-cause death, cardiac death, rehospitalization from any cause, and rehospitalization due to worsening HF
Methodological detailspropensity-score matched (1:2), single-centre
- Propensity-score matched (1:2)
- Single-centre
Main finding
As reported in the abstract
TT vs NTTHazard ratio (95% CI)P value
All-cause mortality
0.656(0.447–0.961)
P = 0.030Cardiac death
0.599(0.380–0.946)
P = 0.028Any-cause rehospitalization
0.687(0.541–0.872)
P = 0.002HF rehospitalization
0.732(0.565–0.948)
P = 0.018Observational data: associations, not effects.
Original publication
Efficacy of Guideline-Directed Medical Treatment in Heart Failure with Mildly Reduced Ejection Fraction. ESC Heart Fail. Published 15 December 2022. doi:10.
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