Heart failure & cardiomyopathies
Predicted lean body mass, fat mass, and heart failure in patients with type 2 diabetes mellitus
Authors' conclusion
The risk of HF conferred by higher BMI was primarily driven by the association between FMI and HF. After adjusting for BMI, LBMI played a protective role.
Study context
- Population
- Patients with T2DM and cardiovascular disease (CVD) or high CVD risk (ACCORD)
- Comparison
- Higher vs lower fat mass index (FMI), lean BMI (LBMI) and body mass index (BMI)
- Primary endpoint
- HF
Methodological detailspost hoc analysis, Cox proportional-hazards models
- Post hoc analysis
- Cox proportional-hazards models
Primary result
As reported in the abstract
Hazard ratio (95% CI)
FMIeach 1 SD increase in FMI; adjusted
1.72(1.15–2.57)
LBMIprotective; adjusted
0.58(0.38–0.87)
BMIafter further adjusting for FMI
0.97(0.67–1.42)
Each 1 SD increase in FMI, as printed
- Heart failure (HF) occurred
- 356 participants (3.7%)
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| HF, discordant analysis (vs concordant values below the medians)FMI above median, BMI belowvs Concordant below medians | 1.78 (1.14–2.78) | |
| HF, discordant analysis (vs concordant values below the medians)BMI above median, FMI belowvs Concordant below mediansNot associated | 1.09 (0.57–2.09) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Predicted lean body mass, fat mass, and heart failure in patients with type 2 diabetes mellitus. Am Heart J. Published 14 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →