Arrhythmias & electrophysiology
Efficacy of Low-Voltage-Area Ablation Is Enhanced in Patients With Advanced Left Atrial Enlargement: A Subanalysis of the SUPPRESS-AF Trial
Authors' conclusion
The efficacy of LVA ablation in addition to PVI for the treatment of persistent AF was more pronounced in patients with a large left atrium.
Study context
- Population
- Patients with persistent AF and left atrial low-voltage-area (LVAs)
- Participants
- 170 vs 172
- Comparison
- LVA ablation group vs pulmonary vein isolation (PVI)-alone group
- LVA ablation groupn = 170
- PVI-alone groupn = 172
Methodological detailsrandomized controlled SUPPRESS-AF trial
- Randomized controlled SUPPRESS-AF trial
Primary result
As reported in the abstract
Atrial fibrillation or atrial tachycardia recurrence-free rate, LAD>44 mm vs ≤44 mm
Further findings
Atrial fibrillation or atrial tachycardia recurrence-free rate among patients with a LAD>44 mm
Atrial fibrillation or atrial tachycardia recurrence-free rate among patients with a LAD≤44 mm
- Atrial fibrillation or atrial tachycardia recurrence-free rate among patients with a left atrial diameter (LAD)>44 mm: P =0.016
- Atrial fibrillation or atrial tachycardia recurrence-free rate among patients with a LAD≤44 mm: P =0.986
Original publication
Efficacy of Low-Voltage-Area Ablation Is Enhanced in Patients With Advanced Left Atrial Enlargement: A Subanalysis of the SUPPRESS-AF Trial. Circ Arrhythm Electrophysiol. Published 26 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it