Arrhythmias & electrophysiology
Impact of renal function on the efficacy of low-voltage area ablation after pulmonary vein isolation: a sub-analysis of the SUPPRESS-AF trial
Authors' conclusion
In patients with renal dysfunction, LVA ablation after PVI reduced AF recurrence after radiofrequency catheter ablation for persistent AF.
Study context
- Population
- Patients undergoing initial radiofrequency catheter ablation for persistent atrial fibrillation (AF) with low-voltage area (LVAs) ≥5 cm²
- Participants
- 341 patients
- Comparison
- Pulmonary vein isolation (PVI) + LVA ablation vs PVI alone, stratified by renal function
- Primary endpoint
- Recurrence of atrial tachyarrhythmias
- Follow-up
- 12 months following ablation
Methodological detailsmulticentre, prospective, open-label, subgroup analysis by chronic kidney disease (CKD) stage
- Multicentre
- Prospective
- Open-label
- Subgroup analysis by CKD stage
Primary result
As reported in the abstract
Freedom from primary outcome, by CKD stage (subgroups) · 12 months
- PVI + LVA-ABL vs PVI-alone: P = 0.59
- PVI + LVA-ABL vs PVI-alone: P = 0.004
Further findings
Primary outcome, overall cohort
- Patients developing the primary outcome
- 146 (43%)
- Mean estimated glomerular filtration rate (eGFR) (mL/min/1.73 m²)
- 60 ± 16
Original publication
Impact of renal function on the efficacy of low-voltage area ablation after pulmonary vein isolation: a sub-analysis of the SUPPRESS-AF trial. Europace. Published 2 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it