Arrhythmias & electrophysiology
Electrical and mechanical interventricular dyssynchrony coupling in patients with bradycardia: A ultra-high-frequency electrocardiography (UHF-ECG) validation trial
Authors' conclusion
UHF-ECG noninvasively expresses interventricular dyssynchrony from V7-V1 chest leads with similar results to echocardiography. RVP increases interventricular dyssynchrony, while CSP preserves synchronous ventricular activation.
Study context
- Population
- Patients with advanced atrioventricular conduction disease and preserved ventricular systolic function receiving right ventricular pacing or conduction system pacing
- Participants
- 53 patients
- Comparison
- UHF-ECG interventricular electrical dyssynchrony (e-DYS) vs interventricular mechanical delay (IVMD) measured by echocardiography
- Right ventricular pacing (RVP)n = 32 [60 %]
- Conduction system pacing (CSP)n = 21 [40 %]
- Outcome
- Baseline IVMD vs interventricular e-DYS, entire population
- Follow-up
- Baseline
Methodological detailsprospectively assigned
- Prospectively assigned
Performance
As reported in the abstract
IVMD (median [IQR])
−2 [−8 to 5] ms
Interventricular e-DYS (median [IQR])
−1 [−6 to 5] ms
Further findings
IVMD vs interventricular e-DYS in the RVP group · after pacemaker implantation
- IVMD
- 28 [23-33] ms
- Interventricular e-DYS
- 26 [19-33] ms
- P=.99
- Both increased in the RVP group
IVMD vs interventricular e-DYS in the CSP group · after pacemaker implantation
- IVMD
- −7 [−16 to 2] ms
- Interventricular e-DYS
- −5 [−12 to 2] ms
- P=.91
- Remained low in the CSP group
Correlation between IVMD and interventricular e-DYS for all studied ventricular rhythms
- Moderate overall correlation (R)
- 0.74
Age
- Median age (interquartile range)
- 75 (interquartile range 72-80) years
- Both groups had similar clinical characteristics
Original publication
Electrical and mechanical interventricular dyssynchrony coupling in patients with bradycardia: A UHF-ECG validation trial. Heart Rhythm. Published 21 February 2025. doi:10.
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