Arrhythmias & electrophysiology
Hypertensive vs. normotensive blood pressure response to advanced conduction disorders: comparison of baseline non-invasive haemodynamic evaluation
Authors' conclusion
Haemodynamic presentations in high-degree AV block are heterogeneous. A hypertensive response represents a distinct clinical phenotype characterized by preserved cardiac function, higher escape rhythms, increased PVR, and fewer end-organ hypoperfusion signs.
Study context
- Population
- Patients with advanced conduction disorders (high-degree atrioventricular (AV) block) undergoing pacemaker implantation, October 2020 to December 202273 with haemodynamic assessment
- Participants
- 261 patients
- Exposure
- Hypertensive vs normotensive vs unstable BP response to high-degree AV block
- Normotensiven = 99reference
- Hypertensiven = 118
- Unstablen = 44
- Outcome
- Haemodynamic profile by BP response
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
| Group | Value | Escape rhythm | EF | Hypertension history |
|---|---|---|---|---|
| Normotensive | 37.9% | 38.1 ± 9.9 | 53.9 ± 11 | |
| Hypertensive | 45.2% | 39.1 ± 6.7 | 58.2 ± 8 | 77.1% |
| Unstable | 16.9% | 31.5 ± 10.4 | 53.2 ± 12 |
Value
Normotensive37.9%
Hypertensive45.2%
Unstable16.9%
Escape rhythm
Normotensive38.1 ± 9.9
Hypertensive39.1 ± 6.7
Unstable31.5 ± 10.4
EF
Normotensive53.9 ± 11
Hypertensive58.2 ± 8
Unstable53.2 ± 12
Hypertension history
Normotensive— not stated in the abstract
Hypertensive77.1%
Unstable— not stated in the abstract
Observational data: associations, not effects.
Further findings
Mortality
- Unstable had the highest 30-day mortality
- Higher 1-year mortality in Unstable, not statistically significant
Factors independently associated with hypertensive response
- Higher heart rate, higher EF, calcium channel blocker pre-treatment
Original publication
Hypertensive vs. normotensive blood pressure response to advanced conduction disorders: comparison of baseline non-invasive haemodynamic evaluation. Eur Heart J Acute Cardiovasc Care. Published 4 August 2025. doi:10.
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