Heart failure & cardiomyopathies

Electrical Resynchronization and Clinical Outcomes During Long-Term Follow-Up in Intraventricular Conduction Delay Patients Applied Left Bundle Branch Pacing-Optimized Cardiac Resynchronization Therapy

Circ Arrhythm ElectrophysiolPublished Nonrandomised comparative study

Authors' conclusion

LOT-CRT improves ventricular electrical synchrony and may provide greater clinical outcomes as compared with BiV-CRT in intraventricular conduction delay patients.

Study context

Population
Patients with intraventricular conduction delay and CRT indications
Participants
30 vs 55
Comparison
LOT-CRT vs BiV-CRT
  • LOT-CRTn = 30
  • BiV-CRTn = 55reference
Outcome
QRS duration reduction
Methodological detailsconsecutive patients
  • Consecutive patients

Main finding

As reported in the abstract

P < 0.001

Further findings

Implant success rate

LVEF · 6 months

P < 0.05

LVEF · 12 months

P < 0.05

LVEF · 18 months

P < 0.005

LVEF · 24 months

P < 0.05

OutcomeHRP value
Adverse clinical outcomes (HF rehospitalization and mortality) · 24 months0.33P = 0.035

Original publication

Electrical Resynchronization and Clinical Outcomes During Long-Term Follow-Up in Intraventricular Conduction Delay Patients Applied Left Bundle Branch Pacing-Optimized Cardiac Resynchronization Therapy. Circ Arrhythm Electrophysiol. Published 14 August 2023. doi:10.1161/circep.122.011761

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