Heart failure & cardiomyopathies
Growth differentiation factor-15 in patients with or at risk of heart failure but before first hospitalisation
Authors' conclusion
In patients at risk of HF, or with HF but before first hospitalisation, GDF-15 provides unique information and is highly predictive of hospitalisation for HF or all-cause mortality, leading to more accurate risk stratification that can improve clinical decision making.
Study context
- Population
- Patients in stage A-C heart failure (HF) (at risk of HF or with HF, before first hospitalisation) undergoing CMR and GDF-15 measurement
- Participants
- 2,166 patients
- Outcome
- Composite of:
- First hospitalisation for HF
- All-cause mortality
- Follow-up
- Median 1093 (939-1231) days
Methodological detailslongitudinal, consecutive patients
- Longitudinal
- Consecutive patients
Main finding
As reported in the abstract
Prognostic value of GDF-15 for HF hospitalisation or all-cause mortality
Log-transformed GDF-15 strongest predictor of outcome, HR
2.12
95% CI 1.71 to 2.63
Continuous Net Reclassification Improvement of risk model
0.26
95% CI 0.13 to 0.39
Observational data: associations, not effects.
Further findings
Determinants of GDF-15
- Major determinants: age, DM and NT-proBNP; variability explained (R2)
- 0.51
Original publication
Growth differentiation factor-15 in patients with or at risk of heart failure but before first hospitalisation. Heart. Published 11 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →