Electrocardiographic and Echocardiographic Markers of Atrial and Ventricular Remodeling Allow Identification of Cardiac Sarcoidosis
Authors' conclusion
An exploratory multimodal, noninvasive approach integrating atrial and ventricular ECG and TTE markers provides high diagnostic accuracy for identifying CS and may serve as a pragmatic screening and triage tool to guide referral for advanced cardiac imaging. Clinical Trial Registration DRKS00031557 on drks.de (German Clinical Trials Register).
Study context
- Population
- Patients with biopsy-proven sarcoidosisconsecutive patients with biopsy-proven sarcoidosis
- Participants
- 252 patients
- Index test or model
- Combined diagnostic model integrating electrocardiography (ECG) and TTE parameters vs cardiac sarcoidosis (CS) defined by characteristic findings on positron emission tomography-computed tomography (PET-CT) or cardiac magnetic resonance imaging
- Target condition
- Cardiac sarcoidosis (CS)
Methodological detailsexploratory
- Exploratory
Performance
As reported in the abstract
| Test or model | AUROC |
|---|---|
| ECG-based model | 0.87 |
| TTE-based model | 0.87 |
| Combined ECG/TTE model | 0.90 |
AUROC
ECG-based model0.87
TTE-based model0.87
Combined ECG/TTE model0.90
Further findings
Prevalence of CS
- CS identified
- 37 (14.7%)
ECG markers independently associated with CS
- Prolonged P-wave duration, prolonged QRS duration, and reduced T-wave amplitude in lead aVR independently associated with CS
TTE predictors of CS
- Increased left atrial volume index, increased left ventricular end-diastolic diameter, and impaired left ventricular global longitudinal strain emerged as significant predictors
Original publication
Electrocardiographic and Echocardiographic Markers of Atrial and Ventricular Remodeling Allow Identification of Cardiac Sarcoidosis. JACC Clin Electrophysiol. Published 5 November 2026. doi:10.
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