Arrhythmias & electrophysiology
Electrocardiographic markers of subclinical atrial fibrillation detected by implantable loop recorder: insights from the LOOP Study
Authors' conclusion
We identified several ECG parameters associated with new-onset subclinical AF detected by ILR. Especially PWD and IAB were robustly related to the onset and the burden of AF as well as progression over time.
Study context
- Population
- Atrial fibrillation (AF)-naïve individuals aged 70–90 years with additional stroke risk factors undergoing implantable loop recorder (ILR) monitoring
- Participants
- 1,370 individuals
- Comparison
- Baseline 12-lead electrocardiogram (ECG) parameters and subclinical AF detected by ILR
- Primary endpoint
- AF detection (≥6 min), cumulative AF burden, long-lasting AF (≥24 h) and AF progression
Primary result
As reported in the abstract
New-onset AF (≥6 min)
Developed AF during follow-up
419
30.6%
Mean cumulative AF burden
1.5%
95% CI 1.2–1.8
Further findings
AF progression among AF patients
- Reduction in cumulative AF burden over time, IRR
- 0.70 [95% CI: 0.51-0.96] (95% CI)
- Interatrial block (IAB) and progression to AF ≥24 h, HR
- 1.86 [95% CI: 1.02-3.39] (95% CI)
- Longer P-wave duration (PWD) associated with progression in AF duration (spline analysis)
Original publication
Electrocardiographic markers of subclinical atrial fibrillation detected by implantable loop recorder: insights from the LOOP Study. Europace. Published 18 April 2023. doi:10.
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