Elevated Cardiac Biomarkers, Erectile Dysfunction, and Mortality in U.S. Men: National Health and Nutrition Examination Survey (NHANES) 2001 to 2004
Authors' conclusion
In this national study, the association of erectile dysfunction with elevated hs-troponin and excess mortality risk
Study context
- Population
- US men aged ≥20 years in NHANES 2001–2004
- Participants
- 2,971 men
- Exposure
- Men with vs without erectile dysfunction
- Outcome
- Prevalence of elevated cardiac biomarkers (>90th percentile: NT-proBNP, hs-troponin T, 3 hs-troponin I assays) and their associations with erectile dysfunction and mortality
Methodological detailsNHANES 2001–2004, national survey, logistic regression, Cox regression
- NHANES 2001–2004
- National survey
- Logistic regression
- Cox regression
Main finding
As reported in the abstract
Association of elevated cardiac biomarkers with erectile dysfunction
Erectile dysfunction vs No erectile dysfunctionEstimate (95% CI)
Elevated hs-troponin T (strongest association)
adjusted OR 2.01(1.22–3.30)
Elevated NT-proBNP, not significant
OR 1.22(0.74–2.03)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| All-cause mortality · median 16 years of follow-up | 1.23 (1.04–1.46) | |
| 0.512Adjusted hazard ratio (log scale) |
- All-cause mortality — Deaths during follow-up
- 673
All-cause and CV mortality, elevated cardiac biomarkers with erectile dysfunction
- Highest risk; adjusted HRs ranging from ≈1.5 to 2.4
Original publication
Elevated Cardiac Biomarkers, Erectile Dysfunction, and Mortality in U.S. Men: NHANES 2001 to 2004. JACC Adv. Published 30 June 2023. doi:10.
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