Triglyceride-rich lipoprotein remnants, low-density lipoproteins, and risk of coronary heart disease: a UK Biobank study
Authors' conclusion
Distinct SNP clusters appear to impact differentially on remnant particles and LDL. Our findings are consistent with TRL/remnants having a substantially greater atherogenicity per particle than LDL.
Study context
- Population
- UK Biobank population
- Comparison
- Triglyceride-rich lipoproteins (TRL)/remnant-C vs LDL-C as genetic determinants of coronary heart disease (CHD) risk
- Outcome
- CHD
Methodological detailsmultivariable Mendelian randomization, UK Biobank
- Multivariable Mendelian randomization
- UK Biobank
Main finding
As reported in the abstract
CHD per 1 mmol/L higher cholesterol (multivariable model)
Odds ratio (95% CI)
TRL/remnant-C
2.59(1.99–3.36)
LDL-C
1.37(1.27–1.48)
Per 1 mmol/L higher cholesterol, as printed
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| CHD per SD higher apoB, by SNP clusterCluster 2 · per SD higher apoB | 1.76 (1.58–1.96) | |
| CHD per SD higher apoB, by SNP clusterCluster 1 · per SD higher apoB | 1.33 (1.26–1.40) | |
| 0.512Odds ratio (log scale) |
CHD per SD higher apolipoprotein B (apoB), by SNP cluster
- Cluster 2 OR significantly greater than cluster 1; concordant result with polygenic scores
Original publication
Triglyceride-rich lipoprotein remnants, low-density lipoproteins, and risk of coronary heart disease: a UK Biobank study. Eur Heart J. Published 26 June 2023. doi:10.
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