Heart failure & cardiomyopathies
Eligibility and Projected Benefits of Rapid Initiation of Quadruple Therapy for Newly Diagnosed Heart Failure
Authors' conclusion
In this nationwide U.S. cohort of patients hospitalized for newly diagnosed HFrEF, >4 of 5 patients were projected as eligible for quadruple therapy at discharge; yet, <1 in 6 were prescribed it.
Study context
- Population
- Patients hospitalized for newly diagnosed heart failure with reduced ejection fraction (HFrEF), US GWTG-HF registry, 2016–2023
- Participants
- 33,036 patients
- Exposure
- Quadruple therapy vs ACEi/ARB and beta-blocker vs no GDMT
- Outcome
- Eligibility for quadruple therapy; projected 12-month mortality with quadruple therapy
- Follow-up
- 12 months
Methodological detailsnationwide, Get With The Guidelines-Heart Failure registry
- Nationwide
- Get With The Guidelines-Heart Failure registry
Main finding
As reported in the abstract
Eligibility for GDMT
Eligible for quadruple therapy
27,158
82%
Eligible for ≥3 components
30,613
93%
Observational data: associations, not effects.
Further findings
| Outcome | Absolute risk reduction |
|---|---|
| Projected 12-month mortality with complete implementation of quadruple therapy by discharge · 12 monthsQuadruple therapy vs ACEi/ARB and beta-blocker · NNT = 10 | 10.4% |
| Projected 12-month mortality with complete implementation of quadruple therapy by discharge · 12 monthsQuadruple therapy vs No GDMT · NNT = 4 | 24.8% |
- Projected 12-month mortality with complete implementation of quadruple therapy by discharge: projected by applying relative risk reductions from clinical trials
Prescription among patients eligible for quadruple therapy · 2021 to 2023
- Prescribed quadruple therapy
- 15.3%
- Prescribed triple therapy
- 41.5%
Observed outcomes in Medicare beneficiaries eligible for quadruple therapy · 12 months
- Mortality
- 24.7%
- HF hospitalization
- 22.2%
Original publication
Eligibility and Projected Benefits of Rapid Initiation of Quadruple Therapy for Newly Diagnosed Heart Failure. JACC Heart Fail. Published 25 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →