Pulmonary vascular disease & thromboembolism
Endovascular mechanical thrombectomy vs. catheter-directed thrombolysis in pulmonary embolism: insights from the National Readmission Database
Main finding · In-hospital mortalityResult — go to the resultOdds ratio 1.31 95% CI 1.01–1.68Authors' conclusion
Endovascular CDT was associated with lower in-hospital mortality and major bleeding compared to MT in PE. As hospital procedural volume increased, both these outcomes improved, while difference in outcomes between MT and CDT reduced.
Study context
- Population
- Adults with a primary diagnosis of pulmonary embolism (PE) who underwent either mechanical thrombectomy (MT) or catheter-directed thrombolysis (CDT), 2021 National Readmission Database (NRD)after propensity-score matching
- Participants
- 7,376 vs 7,355
- Exposure
- MT compared with CDT
- MTn = 7,376
- CDTn = 7,355reference
- Outcome
- In-hospital mortality
Methodological detailspropensity-score matching
- Propensity-score matching
Main finding
As reported in the abstract
Odds ratio
1.31
95% CI 1.01–1.68
P = 0.04
By group
MTvs CDT
OR 1.31 (95% CI 1.01–1.68); P = 0.04
Observational data: associations, not effects.
Secondary outcomes
Post-discharge mortality
- No significant differences
All-cause readmissions
- Higher in the MT group
In-hospital mortality and major bleeding by hospital procedural volume (subgroup)
- Higher hospital procedural volumes associated with lower in-hospital mortality and lower major bleeding rates in both MT and CDT
Safety
| Outcome | MT | CDT | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Major bleedingHigher odds with MT | 6.3% | 3.6% | 1.79 (1.39–2.32) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Original publication
Endovascular mechanical thrombectomy vs. catheter-directed thrombolysis in pulmonary embolism: insights from the National Readmission Database. Eur Heart J Acute Cardiovasc Care. Published 23 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →