Arrhythmias & electrophysiology
Epicardial Closure for Peridevice Leaks from Endocardial Left Atrial Appendage Closure – Early LARIAT-4-PDL Registry Results
Authors' conclusion
These initial results suggest that a LARIAT may be an alternative strategy in patients with clinically significant PDLs after endocardial LAA closure. Future studies are needed to corroborate our initial findings and long-term closure results.
Study context
- Population
- Patients with peri-device leaks (PDLs) ≥3 mm after either a Watchman FLX Pro or an Amplatzer Amulet endocardial left atrial appendage (LAA) occluder, as seen on postoperative imaging, who underwent LARIAT for closure of device-related LAA leaks
- Participants
- 10 cases
- Exposure
- Watchman vs Amulet
- Outcome
- Acute LARIAT PDL closure
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- LARIAT PDL closure was successful in all cases
- No difference when stratified by initial endocardial LAA closure type
Observational data: associations, not effects.
Further findings
Procedural and fluoroscopy times
- Procedural time
- 48.7±10.8 min
- Fluoroscopy time
- 7.0±3.7 min
Baseline characteristics
- Age
- 67.2±10.7years
- Female
- 30.0%
- Body mass index
- 32.4±6.4 kg/m²
- CHADSVASC
- 4.4±0.7
- HASBLED
- 3.7±0.7
- Initial Watchman
- 80.0%
- Initial Amulet
- 20.0%
- Average PDL
- 5.4±0.8 mm
- Prior attempted PDL closure with radiofrequency ablation
- 10.0%
- Prior attempted PDL closure with coiling
- 20.0%
- Prior attempted PDL closure with a previous device
- 10.0%
Original publication
Epicardial Closure for Peridevice Leaks from Endocardial Left Atrial Appendage Closure – Early LARIAT-4-PDL Registry Results. Heart Rhythm. Published 22 October 2026. doi:10.
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