Heart failure & cardiomyopathies
Epidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023
Authors' conclusion
In this administrative claims-based study, the prevalence of HCM from 2016 to 2023 was 1/327 individuals, which translates to an estimated 832,956 HCM cases in the United States.
Study context
- Population
- Patients with ≥1 hypertrophic cardiomyopathy (HCM) diagnosis code in administrative claims from the Symphony Integrated Dataverse, United States, 2016 to 2023HCM cases in the total population of 141,003,247 patients
- Participants
- 431,457 patients
- Exposure
- Nonobstructive HCM (nHCM) vs obstructive HCM (oHCM) vs symptomatic HCM
- Outcome
- Prevalence of HCM
- Follow-up
- 2016-2023
Methodological detailspatient-level administrative claims
- Patient-level administrative claims
Main finding
As reported in the abstract
Prevalence rate
1/327 individuals
95% CI 1/326–328
Observational data: associations, not effects.
Further findings
| Outcome | nHCM | oHCM | Symptomatic HCM |
|---|---|---|---|
| Rates in nHCM and oHCM | 188/100,000 (95% CI: 187-189/100,000) | 117/100,000 (95% CI: 117-118/100,000) | — not stated in the abstract |
| Incidence in asymptomatic and symptomatic HCM | — not stated in the abstract | — not stated in the abstract | 135/100,000 (95% CI: 134-135/100,000) |
— not stated in the abstract
- Incidence in asymptomatic and symptomatic HCM: asymptomatic HCM 171/100,000 (95% CI: 171-172/100,000)
- Prevalence by age and sex: males 341/100,000 [95% CI: 339-342/100,000]
- Prevalence by age and sex: females 277/100,000 [95% CI: 275-278/100,000]
Incidence of HCM · 2017 and 2023
- 2017
- 50/100,000 (95% CI: 50-51/100,000)
- 2023
- 56/100,000 (95% CI: 56-57/100,000)
Prevalence by age and sex
- Prevalence generally increased with age
Regional distribution
- Highest HCM, oHCM, and nHCM rates in the Northeast and Midwest
Original publication
Epidemiology of Hypertrophic Cardiomyopathy in the United States From 2016 to 2023. JACC Adv. Published 21 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →