Heart failure & cardiomyopathies
Estimated Pulse Wave Velocity and Risk of New-Onset Heart Failure
Main finding · New-onset HF per 1 m/s increase in ePWVResult — go to the resultHazard ratio 1.35 95% CI 1.33–1.37Authors' conclusion
ePWV was an independent predictor for new-onset heart failure.
Study context
- Population
- Employees without prior HF who attended the 2006–2007 health examination
- Participants
- 98,269 employees
- Exposure
- Per 1 m/s increase in estimated pulse wave velocity (ePWV)
- Outcome
- New-onset HF
- Follow-up
- Average 13.85 ± 1.40 years
Main finding
New-onset HF per 1 m/s increase in ePWV
Hazard ratio
1.35
95% CI 1.33–1.37
ePWV (per 1 m/s)
HR 1.35 (95% CI 1.33–1.37)
Per 1 m/s, as printed
As reported in the abstract
- AUC of ePWV for prediction of HF
- 0.74
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| New-onset HF per 1 m/s ePWV, by subgroupePWV (per 1 m/s) · CV risk factors present | 1.33 (1.31–1.36) | P < 0.01 | |
| New-onset HF per 1 m/s ePWV, by subgroupePWV (per 1 m/s) · CV risk factors absent | 1.59 (1.46–1.73) | P < 0.01 | |
| New-onset HF per 1 m/s ePWV, by subgroupePWV (per 1 m/s) · male | 1.33 (1.31–1.36) | P < 0.01 | |
| New-onset HF per 1 m/s ePWV, by subgroupePWV (per 1 m/s) · female | 1.44 (1.38–1.51) | P < 0.01 | |
| New-onset HF per 1 m/s ePWV, by subgroupePWV (per 1 m/s) · <52 years | 1.50 (1.41–1.58) | P < 0.01 | |
| New-onset HF per 1 m/s ePWV, by subgroupePWV (per 1 m/s) · ≥52 years | 1.23 (1.21–1.26) | P < 0.01 | |
| 0.512Hazard ratio (log scale) |
Reclassification after adding ePWV to traditional CV risk model (incl. age and mean arterial pressure)
- Category-free net reclassification index (NRI)
- 0.311
- Improvement in reclassification ability
- 31.1%
- P < 0.01
Original publication
Estimated Pulse Wave Velocity and Risk of New-Onset Heart Failure. ESC Heart Fail. Published 10 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →